Hydrochlorothiazide

Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It is excreted mainly unchanged by the kidneys. This drug should be used cautiously with people with renal or hepatic impairment. This drug can precipitate azotemia and other associated effects of alterations in fluid and electrolyte balance.  It is important to monitor electrolytes, blood … Continue reading “Hydrochlorothiazide”

Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It is excreted mainly unchanged by the kidneys. This drug should be used cautiously with people with renal or hepatic impairment. This drug can precipitate azotemia and other associated effects of alterations in fluid and electrolyte balance.  It is important to monitor electrolytes, blood glucose, BUN, serum creatinine, and uric acids before and throughout therapy. (Skyscape David Drug Guide)

Hydrochlorothiazide

Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It is excreted mainly unchanged by the kidneys. This drug should be used cautiously with people with renal or hepatic impairment. This drug can precipitate azotemia and other associated effects of alterations in fluid and electrolyte balance.  It is important to monitor electrolytes, blood … Continue reading “Hydrochlorothiazide”

Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It is excreted mainly unchanged by the kidneys. This drug should be used cautiously with people with renal or hepatic impairment. This drug can precipitate azotemia and other associated effects of alterations in fluid and electrolyte balance.  It is important to monitor electrolytes, blood glucose, BUN, serum creatinine, and uric acids before and throughout therapy. (Skyscape David Drug Guide)

Vancomycin

Vancomycin Absorption: Poorly absorbed from the GI tract Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys. Half-life in Adults: 5-8 hours (Increases in renal impairment) Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min) Adverse Reactions/Side Effects: Nephrotoxicity … Continue reading “Vancomycin”

Vancomycin

  • Absorption: Poorly absorbed from the GI tract
  • Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys.
  • Half-life in Adults: 5-8 hours (Increases in renal impairment)
  • Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min)
  • Adverse Reactions/Side Effects: Nephrotoxicity
  • Interactions: May cause additive nephrotoxicity with other nephrotoxic and ototoxic drugs (aspirin, aminoglycosides, cyclosporine, loop diuretics)
  • Renal Impairment for IV (adults): An initial loading dose of 750 mg-1 g; serum level monitoring is optimal for choosing maintenance dose in patients with renal impairment.
  • Assessment: Monitor intake and output ratios and daily weight. Cloudy or pink urine may be a sign of nephrotoxicity.
    • May cause an increase in BUN and creatinine levels

Vancomycin

Vancomycin Absorption: Poorly absorbed from the GI tract Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys. Half-life in Adults: 5-8 hours (Increases in renal impairment) Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min) Adverse Reactions/Side Effects: Nephrotoxicity … Continue reading “Vancomycin”

Vancomycin

  • Absorption: Poorly absorbed from the GI tract
  • Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys.
  • Half-life in Adults: 5-8 hours (Increases in renal impairment)
  • Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min)
  • Adverse Reactions/Side Effects: Nephrotoxicity
  • Interactions: May cause additive nephrotoxicity with other nephrotoxic and ototoxic drugs (aspirin, aminoglycosides, cyclosporine, loop diuretics)
  • Renal Impairment for IV (adults): An initial loading dose of 750 mg-1 g; serum level monitoring is optimal for choosing maintenance dose in patients with renal impairment.
  • Assessment: Monitor intake and output ratios and daily weight. Cloudy or pink urine may be a sign of nephrotoxicity.
    • May cause an increase in BUN and creatinine levels

Vancomycin

Vancomycin Absorption: Poorly absorbed from the GI tract Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys. Half-life in Adults: 5-8 hours (Increases in renal impairment) Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min) Adverse Reactions/Side Effects: Nephrotoxicity … Continue reading “Vancomycin”

Vancomycin

  • Absorption: Poorly absorbed from the GI tract
  • Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys.
  • Half-life in Adults: 5-8 hours (Increases in renal impairment)
  • Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min)
  • Adverse Reactions/Side Effects: Nephrotoxicity
  • Interactions: May cause additive nephrotoxicity with other nephrotoxic and ototoxic drugs (aspirin, aminoglycosides, cyclosporine, loop diuretics)
  • Renal Impairment for IV (adults): An initial loading dose of 750 mg-1 g; serum level monitoring is optimal for choosing maintenance dose in patients with renal impairment.
  • Assessment: Monitor intake and output ratios and daily weight. Cloudy or pink urine may be a sign of nephrotoxicity.
    • May cause an increase in BUN and creatinine levels

Vancomycin

Vancomycin Absorption: Poorly absorbed from the GI tract Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys. Half-life in Adults: 5-8 hours (Increases in renal impairment) Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min) Adverse Reactions/Side Effects: Nephrotoxicity … Continue reading “Vancomycin”

Vancomycin

  • Absorption: Poorly absorbed from the GI tract
  • Metabolism: Oral doses excreted primarily in the feces; IV vancomycin eliminated almost entirely by the kidneys.
  • Half-life in Adults: 5-8 hours (Increases in renal impairment)
  • Use Cautiously in renal impairment (dosage reduction required if CCr is less than or equal to 80 mL/min)
  • Adverse Reactions/Side Effects: Nephrotoxicity
  • Interactions: May cause additive nephrotoxicity with other nephrotoxic and ototoxic drugs (aspirin, aminoglycosides, cyclosporine, loop diuretics)
  • Renal Impairment for IV (adults): An initial loading dose of 750 mg-1 g; serum level monitoring is optimal for choosing maintenance dose in patients with renal impairment.
  • Assessment: Monitor intake and output ratios and daily weight. Cloudy or pink urine may be a sign of nephrotoxicity.
    • May cause an increase in BUN and creatinine levels

Rifampin’s effects on the kidney

Rifampin is an antibiotic used to treat tuberculosis. This drug caught my interest as to what effects it would have on the kidney, since this drug is used for the whole duration of treatment and that it changes the color of urine and other body fluids. Some renal side effects that would be seen while taking this drug would be elevations in the BUN and serum uric acid. This drug primarily eliminated by hepatic metabolism, and what we need to watch closely for is hepatotoxicity especially when the patients have some kind of liver disease . Patients taking this drug

Rifampin is an antibiotic used to treat tuberculosis. This drug caught my interest as to what effects it would have on the kidney, since this drug is used for the whole duration of treatment and that it changes the color of urine and other body fluids. Some renal side effects that would be seen while taking this drug would be elevations in the BUN and serum uric acid. This drug primarily eliminated by hepatic metabolism, and what we need to watch closely for is hepatotoxicity especially when the patients have some kind of liver disease . Patients taking this drug should also be educated that the discoloration of body fluids while taking this drug is a harmless effect.

 

Reference : Burcham, Jacqueline & Rosenthal, Laura. (2016). Lehne’s Pharmacology for Nursing Care. (9th ed). Saunders, Elsevier Inc.

 

Rifampin’s effects on the kidney

Rifampin is an antibiotic used to treat tuberculosis. This drug caught my interest as to what effects it would have on the kidney, since this drug is used for the whole duration of treatment and that it changes the color of urine and other body fluids. Some renal side effects that would be seen while … Continue reading “Rifampin’s effects on the kidney”

Rifampin is an antibiotic used to treat tuberculosis. This drug caught my interest as to what effects it would have on the kidney, since this drug is used for the whole duration of treatment and that it changes the color of urine and other body fluids. Some renal side effects that would be seen while taking this drug would be elevations in the BUN and serum uric acid. This drug primarily eliminated by hepatic metabolism, and what we need to watch closely for is hepatotoxicity especially when the patients have some kind of liver disease . Patients taking this drug should also be educated that the discoloration of body fluids while taking this drug is a harmless effect.

 

Reference : Burcham, Jacqueline & Rosenthal, Laura. (2016). Lehne’s Pharmacology for Nursing Care. (9th ed). Saunders, Elsevier Inc.

 

Furosemide

Furosemide Furosemide is a loop diuretic, that works in the loop of Henle, and is used for edema used for edema due to heart failure, hepatic impairment or renal disease and hypertension. 60-70% of the drug is absorbed after oral administration, and even less in renal failure. It’s half life is increased in renal impairment. … Continue reading “Furosemide”

Furosemide

pill-bottle

Furosemide is a loop diuretic, that works in the loop of Henle, and is used for edema used for edema due to heart failure, hepatic impairment or renal disease and hypertension. 60-70% of the drug is absorbed after oral administration, and even less in renal failure. It’s half life is increased in renal impairment. It is to be used cautiously in severe renal impairment because it increases the risk of ototoxicity. It is important to know what other drugs the patient that is taking furosemide is on, due to the increased risk of nephrotoxicity with certain drugs. It is important to monitor electrolytes, glucose levels, uric acid levels and renal function, as well as intake and output.

Source: Skyscape

Furosemide

Furosemide Furosemide is a loop diuretic, that works in the loop of Henle, and is used for edema used for edema due to heart failure, hepatic impairment or renal disease and hypertension. 60-70% of the drug is absorbed after oral administration, and even less in renal failure. It’s half life is increased in renal impairment. … Continue reading “Furosemide”

Furosemide

pill-bottle

Furosemide is a loop diuretic, that works in the loop of Henle, and is used for edema used for edema due to heart failure, hepatic impairment or renal disease and hypertension. 60-70% of the drug is absorbed after oral administration, and even less in renal failure. It’s half life is increased in renal impairment. It is to be used cautiously in severe renal impairment because it increases the risk of ototoxicity. It is important to know what other drugs the patient that is taking furosemide is on, due to the increased risk of nephrotoxicity with certain drugs. It is important to monitor electrolytes, glucose levels, uric acid levels and renal function, as well as intake and output.

Source: Skyscape

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