Cyclosporine is an immunosuppressant drug with major adverse effects on the kidneys. This drug is absorbed in the gastrointestinal tract and widely distributed. After being metabolized by the liver, small bits of it are excreted in urine. Ironically, this nephrotoxic drug is used to prevent rejections of new kidney transplants. Blood levels of this drug must … Continue reading “Cyclosporine and its Effects on the Kidney”
Cyclosporine is an immunosuppressant drug with major adverse effects on the kidneys. This drug is absorbed in the gastrointestinal tract and widely distributed. After being metabolized by the liver, small bits of it are excreted in urine.
Ironically, this nephrotoxic drug is used to prevent rejections of new kidney transplants. Blood levels of this drug must be periodically assessed to ensure that it hasn’t reached toxic levels, and BUN and serum creatinine levels are monitored for kidney damage. Rise in either of these kidney lab values, however, must be further assessed to determine wether the cause is due to kidney damage or rejection of the kidney transplant. Patients who have both renal impairment and rheumatoid arthritis or psoriasis may not receive this drug. Patients who have only renal impairment, or the other two conditions without the renal impairment, may receive this drug, but kidney function must be closely monitored and the dosage may need to be adjusted.
Due to its nephrotoxic effects, patients must be educated on what to report. This includes an increase in blood pressure, hematuria, an increase urinary frequency, decrease in urine output, or cloudy urine.