Class Talk Fall 2016

Gentamicin has a faster absorption rate when it is given by IM injection, IV administration or by topical agents. It is very poorly absorbed orally. It is excreted through the kidneys at >90% unchanged, which makes it very toxic to the kidneys. Specifically gentamicin causes nephrotoxicity, so if there is renal impairment dose adjustments need to be changed, and blood levels need to be monitored to insure nephrotoxicity is not taking place. Other nursing considerations should be to look out for other nephrotoxic drugs when administering gentamicin, since the incidence may be raised in combination with these types of drugs. Also patients taking this medication should be well hydrated in order to help counteract the nephrotoxic factors.

Gentamicin has a faster absorption rate when it is given by IM injection, IV administration or by topical agents. It is very poorly absorbed orally. It is excreted through the kidneys at >90% unchanged, which makes it very toxic to the kidneys. Specifically gentamicin causes nephrotoxicity, so if there is renal impairment dose adjustments need to be changed, and blood levels need to be monitored to insure nephrotoxicity is not taking place. Other nursing considerations should be to look out for other nephrotoxic drugs when administering gentamicin, since the incidence may be raised in combination with these types of drugs. Also patients taking this medication should be well hydrated in order to help counteract the nephrotoxic factors.

Gentamicin has a faster absorption rate when it is given by IM injection, IV administration or by topical agents. It is very poorly absorbed orally. It is excreted through the kidneys at >90% unchanged, which makes it very toxic to the kidneys. Specifically gentamicin causes nephrotoxicity, so if there is renal impairment dose adjustments need to be changed, and blood levels need to be monitored to insure nephrotoxicity is not taking place. Other nursing considerations should be to look out for other nephrotoxic drugs when administering gentamicin, since the incidence may be raised in combination with these types of drugs. Also patients taking this medication should be well hydrated in order to help counteract the nephrotoxic factors.

Gentamicin has a faster absorption rate when it is given by IM injection, IV administration or by topical agents. It is very poorly absorbed orally. It is excreted through the kidneys at >90% unchanged, which makes it very toxic to the kidneys. Specifically gentamicin causes nephrotoxicity, so if there is renal impairment dose adjustments need to be changed, and blood levels need to be monitored to insure nephrotoxicity is not taking place. Other nursing considerations should be to look out for other nephrotoxic drugs when administering gentamicin, since the incidence may be raised in combination with these types of drugs. Also patients taking this medication should be well hydrated in order to help counteract the nephrotoxic factors.

• Pharmacologic Classification: Aminoglycoside.
• IV or IM treatment of serious infections. Acts by inhibiting protein synthesis in bacteria.
• Excretion is mainly renal (>90%) and minimal amounts are metabolized by the liver, making it very toxic to the kidneys when in high toxic levels.
• Half-life increases with renal impairment. (dosage adjustment is necessary with any kind of renal impairment).
• Assessment includes continuously monitoring I&O and daily weight to assess hydration status and renal function.
• Monitor renal function by UA, SG, BUN, and Creatinine.

More info at : https://www.drugs.com/cdi/amikacin.html

• Pharmacologic Classification: Aminoglycoside.
• IV or IM treatment of serious infections. Acts by inhibiting protein synthesis in bacteria.
• Excretion is mainly renal (>90%) and minimal amounts are metabolized by the liver, making it very toxic to the kidneys when in high toxic levels.
• Half-life increases with renal impairment. (dosage adjustment is necessary with any kind of renal impairment).
• Assessment includes continuously monitoring I&O and daily weight to assess hydration status and renal function.
• Monitor renal function by UA, SG, BUN, and Creatinine.

More info at : https://www.drugs.com/cdi/amikacin.html

• Pharmacologic Classification: Aminoglycoside.
• IV or IM treatment of serious infections. Acts by inhibiting protein synthesis in bacteria.
• Excretion is mainly renal (>90%) and minimal amounts are metabolized by the liver, making it very toxic to the kidneys when in high toxic levels.
• Half-life increases with renal impairment. (dosage adjustment is necessary with any kind of renal impairment).
• Assessment includes continuously monitoring I&O and daily weight to assess hydration status and renal function.
• Monitor renal function by UA, SG, BUN, and Creatinine.

More info at : https://www.drugs.com/cdi/amikacin.html

• Pharmacologic Classification: Aminoglycoside.
• IV or IM treatment of serious infections. Acts by inhibiting protein synthesis in bacteria.
• Excretion is mainly renal (>90%) and minimal amounts are metabolized by the liver, making it very toxic to the kidneys when in high toxic levels.
• Half-life increases with renal impairment. (dosage adjustment is necessary with any kind of renal impairment).
• Assessment includes continuously monitoring I&O and daily weight to assess hydration status and renal function.
• Monitor renal function by UA, SG, BUN, and Creatinine.

More info at : https://www.drugs.com/cdi/amikacin.html

• Pharmacologic Classification: Aminoglycoside.
• IV or IM treatment of serious infections. Acts by inhibiting protein synthesis in bacteria.
• Excretion is mainly renal (>90%) and minimal amounts are metabolized by the liver, making it very toxic to the kidneys when in high toxic levels.
• Half-life increases with renal impairment. (dosage adjustment is necessary with any kind of renal impairment).
• Assessment includes continuously monitoring I&O and daily weight to assess hydration status and renal function.
• Monitor renal function by UA, SG, BUN, and Creatinine.

More info at : https://www.drugs.com/cdi/amikacin.html

Vancomycin is an anti-infective that is used to treat serious and potentially life-threatening infections. It should be used cautiously in patients with renal impairment (dosage reduction required if Cc <80 mL/min) because the risk of toxicity increases with high, prolonged blood concentration. Nephrotoxicity can occur when taken with other nephrotoxic drugs such as aspirin, cyclosporine and cisplatin. Patients should be monitored for albumin, casts, or cells in the urine or decreased specific gravity, CBC, and renal function periodically during therapy. It may also increase BUN levels. IV vancomycin is almost entirely eliminated through the kidneys.

Skyscape. (2015). Skyscape Medical Resources (Version 2.4.5)[Mobile application software]. Retrieved from http://itunes.apple.com