- How does it affect the kidneys?
- Eliminated primarily by the kidneys. In patients with renal impairment, halve-lives of the drug increase dramatically
- It can injure cells of the proximal renal tubules
- High trough levels increase toxicity
- It can induced nephrotoxicity that manifest as acute tubular necrosis
- Symptoms: proteinuria, casts in urine, dilute urine, increased creatinine and BUN
- Where is it absorbed?
- Crosses membranes poorly, very little of oral dose is absorbed.
- Well absorbed after IM and IV administration and distributed to the ECF
- Nursing considerations for renal patients?
- Dosage adjustment is necessary for renal impairment
- Increase dosage interval in patients with kidney disease
- Monitor blood levels, serum creatinine & BUN to prevent nephrotoxicity
- Do not combine with other nephrotoxic drugs
Gentamicin!
How does it affect the kidneys? Eliminated primarily by the kidneys. In patients with renal impairment, halve-lives of the drug increase dramatically It can injure cells of the proximal renal tubules High trough levels increase toxicity It can induced nephrotoxicity that manifest as acute tubular necrosis Symptoms: proteinuria, casts in urine, dilute urine, increased creatinine … Continue reading “Gentamicin!”
