Pharmacologic Classification: Aminoglycoside.
- IV or IM treatment of serious infections. Acts by inhibiting protein synthesis in bacteria.
- Excretion is mainly renal (>90%) and minimal amounts are metabolized by the liver, making it very toxic to the kidneys when in high toxic levels.
- Half-life increases with renal impairment. (dosage adjustment is necessary with any kind of renal impairment).
- Assessment includes continuously monitoring I&O and daily weight to assess hydration status and renal function.
- Monitor renal function by UA, SG, BUN, and Creatinine.
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